Will Smith plays Robert Neville; a scientist unable to stop a deadly man-made virus spreading which he is immune to and the only human survivor in New York City and perhaps the world. His townhouse is at 11 Washington Square Park North and if my memory serves me correctly is where he sends out daily radio messages in the desperate hope of finding any other survivors who might be out there.
Just across the road from his apartment is Washington Square which he views from his window. This place would normally be a great place to chill out and relax but sadly when I was there it was absolutely bucketing it down with rain and the arch could offer only a slight respite from the downpour. I have since seen this area featured in a fair few other movies and TV programmes.
The flatiron building at 175 5th Avenue is later seen as he drives around the empty streets of New York. This is a cool looking construction which was completed in 1902 and the Flatiron district around it got its name from the building.